Do peptides actually work for wrinkles?
Peptides are short chains of amino acids used in skincare to help improve the visible look of fine lines, wrinkles, firmness and elasticity. Results depend on the full formula and consistent use.
Peptides are short fragments of proteins. Many naturally occurring proteins in skin are collagen proteins, which help provide firmness and structure. As collagen breaks down over time, visible signs of aging can become more noticeable. Topical formulas with collagen-supporting peptides can help skin appear smoother and firmer.

Peter Thomas Roth products with peptides
- Peptide Skinjection™ Amplified Wrinkle-Fix Serum
- Peptide Skinjection™ Moisture Infusion Cream
- Peptide Skinjection™ Fill + Fix Under-Eye Cream
- Peptide Skinjection™ Peptide Infused Face + Eye Tape
- Instant FIRMx® Eye Temporary Eye Tightener
- Ultimate Solution 5™ Multitasking Moisturizer
- Ultimate Solution 5™ Multitasking Eye Cream
Frequently asked questions
Peptides vs. retinol: which is better?
They work differently. Retinol is a vitamin A derivative used for visible lines, tone and texture; peptides support the visible look of firmness, elasticity and wrinkles. The right choice depends on skin goals and tolerance.
Do peptide serums work like Botox?
No topical serum is the same as an injectable treatment. Peptide Skinjection™ is positioned as non-invasive. Helps prolong the need for your next injectable treatment by up to six months.*
Which peptide products should I use for fine lines and firmness?
Start with Amplified Wrinkle-Fix Serum, add Moisture Infusion Cream and use Fill + Fix Under-Eye Cream around the eyes. Face + Eye Tape can be added as directed.
*Based on an in vivo study on 22 women (51 years average age) who received onetime neurotoxin (boNT-A) injections followed by application of 10% Argirelox™ peptide solution twice daily for six months.